How Many Puffs of Vape are Equal to a Cigarette? EDGE Vaping Great question! Here's a clear comparison of smoking vs. vaping, especially in the context of surgical and skin health (like facelift outcomes): Smoking (Tobacco) WORSE overall Key Harms: Say no to vaping. 10 15 vape puffs are roughly equivalent to one cigarette. We want to encourage and support families to have open and engaging conversations with young people to Step 1: 21 mg Nicotine Patch NICODERM Canada Tobacco and Vaping